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Monoclonal Antibodies for Detection of Rabies Virus Antigen and Confirmatory Rabies Diagnosis

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According to the World Health Organization (WHO), rabies causes greater than 59,000 deaths every year in over 150 countries as of 2017. A rapid and reliable diagnostic test for rabies is critical for prophylaxis considerations in humans bitten by animals as well as for basic surveillance and animal rabies control programs. The World Organization of Animal Health (OIE) and WHO Expert Committee on Rabies recently approved the direct rapid immunohistochemical test (DRIT) for rabies diagnostics.

Inventor First Name: 
Subbian
Lillian
Michael
Pamela
Jason
Joo
Xiaoling
Asiya
Claire
Inventor Last Name: 
Panayampalli
Orciari
Niezgoda
Yager
Goldstein
Lee
Tang
Chida
Hartloge
E Number Only: 
E-054-2021
Inv Is lead: 
Provider Technology ID: 
3438
LPM Zip: 
20892-9804
LPM Organization: 
NIH Office of Technology Transfer
LPM Phone: 
301-443-8518
LPM State: 
MD
Publication Caption: 
PMID 16494761
PMID 23541783
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/ 16494761
https://www.ncbi.nlm.nih.gov/pubmed/ 23541783
  • Antibody
Updated On: 
Friday, March 12, 2021
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Publication Title: 

Lembo, T et al.

Dyer, JL et al.

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Related Patent Application: 

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Related Patent Authority: 
US
PCT
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LPM Last Name: 
Mitzelfelt
LPM FIrst Name: 
Jeremiah
Date Published: 
Friday, March 12, 2021
DTDT Classification: 
Infectious Diseases (viral)
Zoonotic/Veterinary
Diagnostic
Monitoring (Public Health/Counterfeit Detection/Biological)
Quality Control/Quality Assurance
Research Tool
Other (this will include others such as manufacturing, consumer products and vet
Antibody
In vitro data available
In vivo data available (animal)
DTDT Description: 
Infectious Diseases (viral)
Zoonotic/Veterinary
Diagnostic
Monitoring (Public Health/Counterfeit Detection/Biological)
Quality Control/Quality Assurance
Research Tool
Other (this will include others such as manufacturing, consumer products and vet
Antibody
In vitro data available
In vivo data available (animal)
Collaboration Sought: 
Yes
Collaboration Opportunity: 

The CDC Technology Transfer Office (TTO) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize - Monoclonal Antibodies for Detection of Rabies Virus Antigen and Definitive Rabies Diagnosis. For collaboration opportunities, please contact CDC TTO at tto@cdc.gov or 1-404-639-1330.

Advantages: 
  • The first cocktail of two monoclonal antibodies has the ability to detect all the rabies virus (RABV) variants that circulate in North America
  • The second cocktail of two different mAbs should be able to detect non-rabies lyssaviruses found outside the Americas
  • DRIT Reagent 1 has demonstrated sensitivity greater than 99% and specificity of 100% for detection of RABV antigen and non-rabies lyssaviruses antigen. DRIT Reagent 2 is still under evaluation and its sensitivity and specificity information will be updated in the future.
  • Rapid test for the detection of RABV antigen in approximately 1 hour
  • Alternative method for primary diagnosis of RABV in infected humans or animals
  • Useful test for low-resource settings requiring only a light microscope and refrigeration for long-term storage of reagents
Applications: 
  • Part of a DRIT kit for rapid detection of RABV antigen
  • Alternative rabies diagnostic and confirmatory testing when the routine DFA test is unavailable
  • Microscopic antigen detection test for field use if held on icepacks or where refrigeration is available
  • Human or veterinary/zoonotic specimen testing
  • Monitoring and public health surveillance
  • Research tool
NIH Ref. No.: 
E-054-2021-0
IC: 
CDC
LPM Address: 
BG 5601FL RM 2G29 MSC 9804 5601 FISHERS LN
LPM City: 
Bethesda
Inventor IC: 
CDC
CDC
CDC
CDC
CDC
CDC
CDC
CDC
CDC
Institute or Center: 
Lead Inventor: 

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